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The Panther Chameleon is a reptile native to northern Madagascar. They're around 30-50 cm in length with males being larger than females. Their toes fused into two parts of two and three toes, making them look like tongs. They can grab and climb on branches easily. Their upper and lower eyelids fused together and only left a hole big enough for the pupil. Their eyes can see all around their body and move independently, enabling them to focus on two separate objects at the same time. Their tongue is usually longer than their entire body and can shoot forward rapidly. Its tip is coated in sticky mucus to catch their prey.

Panther Chameleons do not change their colour to hide, but rather as a form of visual communication. Their colour range depends on which local subregion they live in. Males are more vibrantly coloured while females tend to be brown or orange. During mating season in summer, females will change to lighter colours to signal desire to mate and once she carries eggs, she will turn dark brown or black. Males are very territorial and will fight other males by changing colours and inflating themselves to appear more intimidating.

Panther Chameleons have been introduced to Mauritius and Reunion. They're popular as pets and easy to care for. They should be kept solitary as they're very territorial in the wild and males kept together will fight each other. Wild populations used to be threatened by exports as pets but strict trade laws have eliminated trade as a threat. Chameleons are at the bottom of the food chain and snakes, birds and even monkeys prey on them.

Kemono Friends' Panther Chameleon appeared in the Nexon Game, Anime, Festival and Pavilion. As opposed to her real life counterpart, she is able to willingly turn invisible. She's good at camouflage and ambushing, though she has trouble with opponents that do not move. Her outfit is a green school uniform with white accents and ribbon, alongside a black sash. Underneath her skirt, she wears black compression shorts. She also has several ninja themed pieces on her costume, such as a hood with an armored 'crown', which has scales, gauntlets, which also has scales, and bandaged legs with sandals. Her hair is green and yellow, tied in a ponytail which coils around to resemble a chameleon's tail, and has red eyes. Like other Friends she has a tail that resembles that of her animal form. Her Unique behaviour has her accidentally launch the Paper Shuriken toy into the air which then falls onto her head and cause her to go invisible out of shame.